Dr Nathalie Mahé

Faculté des Sciences Pharmaceutiques et Biologiques
Université Paris Descartes
Laboratoire de Chimie Physique - Case 23
4 avenue de l'Observatoire
75006 Paris - FRANCE

Phone : + 33 (0) 1 53 73 96 74

nathalie.mahe (at) parisdescartes.fr

Update : 06-Jan-2014

Education and training - Skills - Contract of research - Patent and Communications List

Education and training


2006

Associate Professor and Teacher
Paris, France

Faculté de Pharmacie - Université Paris Descartes

EA 4066 - EAD Physico-Chimie Industrielle du Médicament
IMTCE : Institut Médicament Toxicologie Chimie Environnement

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2005

Research and Teaching Position
Mulhouse, France

Research areas
Nanozeolites : synthesis, crystallization mechanism and application
Supervisor : Valentin Valtchev

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2003-2004

Research and Teaching Position
Rennes, France

Laboratoire De Chimie du Solide et Inorganique Moléculaire de Rennes
Powder Crystallography and Reactivity of Solids

Research areas
New porous materials based on Cd, Zr, Sc, Rare Earths with oxalate or squarate groups. These compounds are synthesized, structurally characterized (single-crystal and powder diffraction) and their thermal decomposition into nanocrystalline oxides are studied
Supervisors : Nathalie Audebrand and Thierry Bataille

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2000 - 2003

Ph.D. in Solid State Chemistry and Inorganic Molecular
8 September 2003
Rennes, France

INSA Rennes, National French Institute of the Applied Sciences
GRCM, Research Group of Chemistry and Metallurgy
Laboratory of Inorganic Materials Chemistry & Inorganic Chemistry of the Lanthanides

Ph.D. financed by a allowance of the French Ministry of the Research

Thesis supervisor : Prof. Olivier Guillou

New molecular precursors : polynuclear lanthanide complexes. Synthesis and structural, physicochemical characterisation

 
Jury’s members
 

Pr. Miguel JULVE OLCINA
Univ. Valence - Espagne

Pr. Talal MALLAH
Univ. Orsay, Paris XI - France

Pr. Yves JOURNAUX
Univ. Jussieu, Paris VI - France

Pr. Jean-Yves SAILLARD
Univ. Rennes 1 - France

Dr Jean-Yves CHANE-CHING
Société Rhodia Recherches - France

Pr. Olivier GUILLOU
INSA Rennes - France

Research areas
Synthesis of new lanthanide clusters, lanthanide-copper and rare earths hydroxides systems
Powder and single-crystal X-Ray diffraction characterization magnetic properties
Thermal studies and spectroscopy

Collaborations
Rhodia Recherche, Aubervilliers, France
Laboratory for Molecular Magnetism of the University of Florence, Italie
for the magnetic measurements

Keywords
Molecular magnetism, lanthanides, clusters, hydrolyses, structural characterization of single-crystals, magnetism, coordination chemistry, synthesis in solutions, crystallizations

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2000

D.E.A. in Solid State Chemistry and Inorganic Chemistry
Preparation to the PhD course
- (equiv. Master)
Good honours degree

INSA Rennes, Rennes University, France

One-year degree required before doctoral studies
Equivalent to a Master's Degree

Training
Synthesis in solutions of materials and clusters of rare earths
Supervisor : Olivier Guillou

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1999

Maîtrise in Chemistry - Solid State Chemistry

Nantes University

Four-year university degree

Training
Synthesis by sol-gel routes and characterization of a lithium and vanadium oxide, LiV3O8
Materials for positive electrode of lithium batteries
Supervisor : Yves Piffard
IMN, Nantes Materials Institute

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Skills

Crystallogenesis

Crystal Growth
Slow diffusion in gels and slow evaporation
Hydrothermal route
Polymorphs and Solvates of drugs


Crystallography
Single-crystal Diffraction
Diffractometer Nonius Kappa CCD, Diffractometer Enraf-Nonius CAD4. Structural analyses with ABSEN, SHELXS, SHELXL, SIR (WINGX and OSCAIL)

Powder Diffraction
Diffractometers : Siemens D500, Bruker AXS D5005, INEL CPS120, CGR, Rigaku, STOE Stadi-p.
X-Ray Powder Diffractometers (Bragg-Brentano and Debye-Scherrer with Lidemann capillaries); softwares DIFFRAC-AT (Bruker), DATASCAN (Philips)
Phase research with software EVA, X’Pert HighScore, WINPLOTR
Structure solution with DIFFRAC-AT, EVA, WINPLOTR, DICVOL (indexing), EXPO, SHELXS and SHELXL (structural analysis), FULLPROF (Rietveld method)
DIAMOND and POWDERCELL (computing molecular graphics).

Thermal analysis Thermodiffractometry, TG, DTA, DSC (water pressure and controlled atmosphere)
Spectroscopy UV-Vis and FT-IR Spectrometers (software WINFirst)
Granulometry SEM (Philips XL30), DLS (Malvern Nano-ZS), Laser granulometry (CILAS1064Liquide).
Magnetism Analysis of magnetism data, SQUID
Bibliographic researches with data bases Cambridge Structural Database (CSD)
Powder Diffraction File, ICDD International Center for Diffraction Data

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Contract of research

Contract of research with the ICDD, International Center for Diffraction Data
Philadelphia, U.S.A.
Powder diffraction patterns of inorganic phases with low thermal stability

Within the framework of this contract, I have contributed between October 2003 and October 2004 to data bases Powder Diffraction File of ICDD by providing 7 original diagrams of diffraction

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Patent and Communications

International Patent - Publications - Oral communications - Posters Communications


International Patent

Chane-Ching J-Y., Guillou O., Mahé N.
Praseodymium cluster, aqueous dispersion and solvent-medium dispersion of this cluster, and their preparation process and use for catalyst
Rhodia Electronics and Catalysis, Fr., 19 pp., FR2847248, WO2004048271, 2004.

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Publications

20) Mahé N., Nicolaï B., Barrio M., Perrin M-A., Do B., Tamarit J-L., Céolin R., Rietveld I. B..
Solid-State properties and dehydration behavior of the active pharmaceutical ingredient potassium guaiacol-4-sulfonate
Crystal Growth & Design, 2013, 13(7), 3028-3035.

19) Mahé N., Nicolaï B., Allouchi H., Barrio M., Do B., Céolin R., Tamarit J-L., Rietveld I. B..
Crystal
structure and solid-state properties of 3,4-diaminopyridine dihydrogen phosphate and their comparison with other diaminopyridine salts
Crystal Growth & Design, 2013, 13(2), 708-715.

18) Nicolaï B., Rietveld I.B., Barrio M., Mahé N., Tamarit J-L., Céolin R., Guéchot C., Teulon J-M.
Uniaxial Negative Thermal Expansion in Crystals of Tienoxolol
Structural Chemistry , 2013, 24, 279-283.

17) Mahé N., Do B., Nicolaï B., Rietveld I.B., Barrio M., Tamarit J-L., Céolin R., Guéchot C., Teulon J-M.
Crystal structure and solid-state studies of aged samples of tienoxolol, an API designed against hypertension

International Journal of Pharmaceutics , 2012, 422, 47-51.

16) Rietveld I. B., Barrio M., Tamarit J-L., Nicolaï B., van de Streek J., Mahé N., Céolin R., Do B. Dimorphism of the Prodrug L-Tyrosine Ethyl Ester: The Pressure-Temperature State Diagram and the Crystal Structure of Phase II
J. Pharm. Sci., 2011, 11, 4774-4782.

15) Waldschmidt, A., Rietveld I.B., Couvrat N., Dupray V., Sanselme M., Berton B., Nicolaï B., Mahé N., Petit S., Céolin R., Coquerel G.
About aged heterogeneous liquid inclusions inside organic crystals in relation to crystal formation, structure, and morphology
Crystal Growth and Design, 2011, 11, 2580-2587.

14) Nicolaï B., Mahé N., Rietveld I. B., Céolin R., Barrio M., Tamarit J-L.
Tyrosine Alkyl Esters as Prodrug: The Structure and Intermolecular Interactions of L-Tyrosine Methyl Ester Compared to L-Tyrosine and its Ethyl and n-Butyl Esters
Structural Chemistry, 2011, 22, 649-659.

13) Mahé N. , Perrin M-A., Barrio M., Nicolaï B., Rietveld I. B., Tamarit J-L., Céolin R.
Solid-State Studies of the Triclinic (Z'=2) Antiprotozoal Drug Ternidazole
J. Pharm. Sci., 2011, 100, 2258-2266.

12) Nicolaï B., Mahé N.
Crystal structure of the biclotymol-N,N-dimethylacetamide solvate 1:1 : experimental and theoretical conformational analysis of biclotymol molecule
Structural Chemistry , 2010, 21, 503-510.

11) Calvez G., Guillou O., Daiguebonne C., Car P.-E., Guillerm V., Gerault Y., Le Dret F., Mahé N.
Octahedral hexanuclear complexes involving light lanthanide ions
Inorganica Chimica Acta, 2008, 361, 2349 - 2356.

10) Mahé N., Nicolaï B., Céolin R.
Crystal structure of biclotymol-DMF 1:1 solvate : 2,2' methylenebis (4-chloro-3-methyl-6-isopropylphenol)-N,N' dimethylformamide solvate

Analytical Sciences: X-Ray Structure Analysis Online, 2008, 24, 143-144.
Publication

9) Calvez G., Bernot K., Guillou O., Daiguebonne C., Caneschi A., Mahé N.
Sterically-induced synthesis of 3d-4f one-dimensional compounds:
A new route towards 3d-4f single chain magnets
Inorganica Chimica Acta, 2008, 361, 3997-4003.

8) Mahé N., Nicolaï B., Céolin R.
Crystal structure of biclotymol-DMSO 1:1 solvate : 2,2' methylenebis (4-chloro-3-methyl-6-isopropylphenol)- dimethylsulfoxide solvate

Analytical Sciences: X-Ray Structure Analysis Online, 2008, 24, 193-194.
Publication

7) Tosheva L., Mahé N., Valtchev V.
One-pot template extraction and alumination of BEC-type zeolite
Studies in Surface Science and Catalysis, 2007, 170(1), 616-621.

6) Mahé N., Audebrand N.
Structure and thermal behaviour of ScK(C2O4)2(H2O)2 and InRb1-x(H3O)x(C2O4)2(H2O)2·0.5(H2O) :
Two members of a family of open-framework oxalates with isotypic helical structures and zeolite-like properties

Solid State Science, 2006, 8, 988-999.

5) Kerbellec N., Mahé N., Guillou O., Daiguebonne C., Cador O., Roisnel T., Oushoorn R.L.
Structure and magnetic properties of Ln 2[Cu(opba)] 3(DMSO) 6(H 2O).H 2O compounds with Ln= La-Lu exhibiting ladder like molecular motifs
Inorganica Chimica Acta, 2005, 358, 3246-52.
Publication

4) Mahé N., Guillou O., Daiguebonne C., Gérault Y., Caneschi A., Sangregorio C., Chane-Ching J-Y., Car P-E., Roisnel T.
Polynuclear Lanthanide Hydroxo Complexes : New Chemical Precursors for Coordination Polymers
Inorg. Chem., 2005, 44(22), 7743-7750.
Publication

3) Bataille T., Mahé N., Le Fur E., Pivan J-Y., Louër D.
Using the parallel-tempering algorithm to overcome complex problems in structure determination of inorganic materials with laboratory X-rays
Z. Kristallogr. Suppl, 2005, 23, 9-14.
Publication

2) Mahé N., Bataille T.
Synthesis, crystal structure from single-crystal and powder X-ray diffraction data, and thermal behaviour of new mixed potassium lanthanide squarates : thermal transformations of layered [Ln(H 2O) 6]K(H 2C 4O 4)(C 4O 4) 2 into pillared LnK(C 4O 4) 2 (Ln = Y, La, Gd, Er)
Inorg. Chem., 2004, 43, 8379-86.
Publication

1) Chane-Ching J-Y., Guillou O., Mahé N.
Praseodymium cluster, aqueous dispersion and solvent-medium dispersion of this cluster, and their preparation process and use for catalyst
Rhodia Electronics and Catalysis, Fr., 19 pp., FR2847248, WO2004048271, 2004.

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Oral communications

Mahé, N.
Open-framework inorganic materials
22 November 2004, Mulhouse, France

Mahé, N.
Open-framework inorganic materials
2 November 2004, Limoges, France

Bataille, T. / Mahé, N. / Le Fur, E. / Pivan, J-Y. / Louër, D.
Using the parallel-tempering algorithm to overcome complex problems in structure determination of inorganic materials with laboratory X-rays
IX. European Powder Diffraction Conference ; 2-5 September 2004, Prague, Czech republic

Mahé, N.
Synthesis, structural characterization and magnetic properties studies of poly-oxo-lanthanates
Defence of half thesis
Jury members : Prof. J.-Y. Saillard and Dr. L. Ouahab
July 2002, Rennes, France

Daiguebonne, C. / Guillou, O. / Mahé, N.
New magnetic precursors : the poly-oxo-lanthanates
GdR Nanomag, 29-30 October 2001, Dourdan, France

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Posters Communications

Rietveld I. B., Barrio M., Nicolaï B., Mahé N., Do B., Céolin R., Tamarit J-L.
Dimorphic L-Tyrosine EthylEster: crystal structure of Phase II and Pressure-Temperature diagram from high-pressure differential thermal analysis and topological inferences
2ème journée scientifique de l'IMTCE , Paris, France, May 27 2011

Nicolaï B., Mahé N., Do B., Rietveld I. B., Barrio M., Tamarit J-L., Céolin R., Guéchot C., Teulon J-M.
Crystal Structure and Solid-State Studies of Tienoxolol
2ème journée scientifique de l'IMTCE , Paris, France, May 27 2011

Rietveld I. B., Barrio M., Nicolaï B., Mahé N., Do B., Céolin R., Tamarit J-L.
Dimorphic L-Tyrosine EthylEster: crystal structure of Phase II and Pressure-Temperature diagram from high-pressure differential thermal analysis and topological inferences
XXXVIIèmes Journées d'Etude des Equilibres entre Phases, Saint-Avold, France, March 30 April 1st 2011

Nicolaï B., Mahé N., Do B., Rietveld I. B., Barrio M., Tamarit J-L., Céolin R., Guéchot C., Teulon J-M.
Crystal Structure and Solid-State Studies of Tienoxolol
AECCPCM, Angers, France, March 31 & April 1st 2011

Mahé N., Nicolaï B., Perrin M-A., Tamarit J-L., Veglio N., Barrio M., Céolin R., Espeau P. Solid State Studies of Ternidazole an Antiprotozoal Drug: Crystal Structure and P-T State Diagram ASSA International workshops, IWPCPS-12, Lille, France, June 21-24, 2010

Perrin M-A., Mahé N., Nicolaï B., Tamarit J-L., Veglio N., Barrio M., Céolin R., Espeau P.
Solid State Studies of Ternidazole an Antiprotozoal Drug: Crystal Structure and P-T State Diagram
XXXVèmes Journées d'Etude des Equilibres entre Phases, Annecy, France, March 2009

Audebrand N., Mahé N., Raite S.
Nouvelles topologies de matériaux hybrides poreux à base d’oxalates : Rôle d’agent structurant des contre-cations
AFC, Rennes, France, July 2008

Tosheva L., Mahé N., Valtchev V.
One-pot template extraction and alumination of BEC-type zeolite
15th International Zeolite Conference (IZC), Beijing, China, August 12-17 2007

Mahé N., Nicolaï B., Espeau P., Céolin R.
Crystallographic and calorimetric studies of some solvates of biclotymol, 2,2'-methylenebis(4-chloro-3-methyl-6-isopropylphenol)

XXXIIIèmes Journées d'Etude des Equilibres entre Phases, Lyon, March 2007

Mahé, N. / Guillou, O. / Chane-Ching, J. Y. / Gérault, Y. / Daiguebonne, C. / Roisnel,T.
Polynuclear lanthanide hydroxo complexes
5 th International Conference on f-elements, 24-29 August 2003, Geneva, Switzerland

Mahé, N. / Guillou, O. / Chane-Ching, JY / Gérault, Y. / Daiguebonne, C. / Roisnel, T. / Sangregorio, C
Polynuclear lanthanide hydroxo complexes
Workshop: «Molecular Materials: From Synthesis to Applications»
23-26 October 2002, Paris, France

Mahé, N. / Guillou, O / Chane-Ching, JY / Gérault, Y. / Daiguebonne, C. / Roisnel, T. / Sangregorio, C
Polynuclear lanthanide hydroxo complexes via lanthanide salts direct hydrolysis
23 Rare Earth research conference 13-18 July 2002, Davis, California, U.S.A.

Mahé, N. / Guillou, O. / Chane-Ching, J.Y. / Daiguebonne, C. / Roisnel, T.
Polynuclear lanthanide complexes
«Days of the Ph.D. Students 2002», 11 December 2002, Rennes, France

Mahé, N.
Lanthanide Clusters “Doctoriales” 2002; 24-29 Nov.; Lorient, France

Mahé, N. / Guillou, O. / Daiguebonne, C. / Caneschi, A. / Sangregorio, C. / Chane-Ching, J. Y.
Oxo-Hydroxo Lanthanide Clusters via the direct hydrolysis route
Galerne 2002, 8-13 September, Clermont-Ferrand, France

Mahé, N. / Guillou, O. / Daiguebonne, C.
Clusters of Poly-oxo-lanthanates
«Days of the Ph.D. Students 2001 » 12 December 2001, Rennes, France

Mahé, N. / Guillou, O. / Daiguebonne, C. / Caneschi, A.
Synthesis, characterization and studies of polyoxolanthanates
Galerne 2001, 23-27 September, Mulhouse, France

Baux, C. / Mahé, N. / Gérault, Y. / Guillou, O.
Reactivity of lanthanides ions in solution (sulfur complexes and nano materials)
Days of Molecular Magnetism, 23-24 January 2001; Bordeaux (France).

Mahé, N. / Daiguebonne, C. / Guillou, O. / Boubekeur, K.
Synthetic route studies of oxo-hydroxo lanthanide clusters
«Days of the Doctoral School Materials Sciences» 13 December 2000, Rennes, France

Mahé, N. / Guillou, O. / Daiguebonne, C. / Boubekeur, K.
Synthesis and studies of lanthanides clusters
Congress of the French Chemistry Society (SFC) 2000, 18-22 September, Rennes, France

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